[Home]
[Full version]
Overweight adolescents projected to have more heart disease in young adulthood
Dec 06 ,Medicine & Health
A new study investigating the health effects of being overweight during adolescence projects alarming increases in the rates of heart disease and premature death by the time today’s teenagers reach young adulthood.
Findings of the study are reported in the Dec. 6, 2007 issue of the “New England Journal of Medicine.”
A team of researchers at the University of California, San Francisco and Columbia University Medical Center used a computer-based statistical modeling system known as the Coronary Heart Disease (CHD) Policy Model to estimate the potential impact of an increasingly overweight U.S. adolescent population on future adult health nationwide.
Based on the numbers of overweight adolescents in 2000, the study found that up to 37 percent of males and 44 percent of females will be obese when these teenagers turn 35 years old in 2020. As a consequence of this obesity, these young adults are expected to have more heart attacks, more chronic chest pain and more deaths before they reach age 50.
The model also estimated more than 100,000 extra cases of heart disease by 2035, which is a 16 percent increase over today’s figures, and a rise in obesity-related CHD deaths by as much as 19 percent.
“Today’s adolescents are the young adults of tomorrow – young adults who would ordinarily be working, raising their families, and not worried about heart disease until they are much older. Our study suggests that more of these young adults will have heart disease when they are 35-50 years old, resulting in more hospitalizations, medical procedures, need for chronic medications, missed work days and shortened life expectancy,” said Kirsten Bibbins-Domingo, PhD, MD, lead author on the study and assistant professor in medicine, epidemiology and biostatistics at UCSF.
“This study highlights the importance of preventing obesity before it starts in children. The current high rate of overweight is not just a problem for adolescents and their parents, it’s something that will affect all of us well into the future,” she added.
The National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention reports that nine million adolescents in the United States are considered overweight, and that childhood obesity rates have tripled since 1970. Eighty percent of overweight adolescents become obese adults, according to other studies.
“We must recall that we all tend to gain weight as we age, so overweight in adolescents means even higher weights later on,” said Lee Goldman, MD, MPH, the senior author and an original developer of the Coronary Heart Disease Policy Model used in the study. Goldman is executive vice president for health and biomedical sciences at Columbia University Medical Center and dean of the medical school there. “Although the general findings of our analysis are not surprising, we were struck by the sheer magnitude of the impact of adolescent obesity and, as a result, how important it is as a public health priority,” he added.
Projections were based on the analysis of data from the U.S. Census Bureau, Medicare program, National Hospital Discharge Survey, NCHS National Health and Nutrition Examination Survey, and other major epidemiological studies of heart disease risk.
The team also investigated whether the negative health impact of obesity could be reversed by treating obesity-related complications like elevated blood pressure and cholesterol levels. Findings indicate that controlling these factors at a young age will help, but heart disease rates could still rise due to the persistent risk of diabetes associated with obesity.
“One of the major health risks for an obese person is becoming diabetic because diabetes increases the risk of heart disease and many other health complications. Unfortunately, it is currently very difficult to lower the likelihood of getting diabetes once a person is obese,” said Bibbins-Domingo.
Source: University of California - San Francisco
Related stories:
Scripps Research scientists define structure of important neurological receptor
Scientists from The Scripps Research Institute have determined the structure of an adenosine receptor that plays a critical role in a number of important physiological processes including pain, breathing, and heart function. The findings could lead to the development of a new class of therapeutics for treating numerous neurological disorders, including Parkinson's and Huntington disease.
Metabolic syndrome ups colorectal cancer risk
In a large U.S. population-based study presented at the 73rd Annual Scientific Meeting of the American College of Gastroenterology, metabolic syndrome patients had a 75 percent higher risk of colorectal cancer compared to those without metabolic syndrome.
New Organic Catalyst Should Improve Drug Development, Lower Costs
(PhysOrg.com) -- Chemists at Oregon State University have developed a new “organocatalyst” that will play a major role in new drug development, greatly reducing costs while making the process more efficient, effective and environmentally friendly.
Reason for sickness absence can predict employee deaths
Employees who take long spells of sick leave more than once in three years are at a higher risk of death than their colleagues who take no such absence, particularly if their absence is due to circulatory or psychiatric problems or for surgery, concludes a study on bmj.com today.
Researchers identify genes associated with increased gout risk
A team of researchers from the United States and the Netherlands has identified mutations in three genes that are associated with high levels of uric acid in the blood, which is a risk factor for gout. The team developed a genetic risk score composed of the number of uric acid-increasing mutations that each person carries (0 to 6), which was associated with up to a 40-fold increased risk for developing gout when comparing persons at lowest and highest risk. The findings are published in the October 4 issue of
The Lancet.
Where you live matters when you're seriously ill
America does a mediocre job caring for its sickest people. The nation, says a new report, gets a C.
Sirtris' review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
Sirtris, a GSK company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 Diabetes, announced today that it published a new review article on the growing body of sirtuin research and its potential to treat diseases of aging such as Type 2 Diabetes, mitochondrial disorders, inflammation, cancer, and heart disease. Entitled "SIRTUINS – Novel Therapeutic Targets to Treat Age-Associated Diseases," the review appears in today's issue of the journal
Nature Reviews Drug Discovery.
Disease diagnosis in just 15 minutes
Testing for diseases such as cancer and multiple sclerosis could soon be as simple as using a pregnancy testing kit.
[Home]
[Full version]