Researchers Discover New Way to Store Information Via DNA

Researchers at UC Riverside have found a way to get into your body and your bloodstream. No, they’re not spiritual gurus or B-movie mad scientists. Nathaniel G. Portney, Yonghui Wu, Stefano Lonardi, and Mihri Ozkan from UCR’s departments of Bioengineering, Computer Science and Engineering, Biochemistry, and Electrical Engineering, and the Center for Nanoscale Science and Engineering, are just talented when it comes to manipulating DNA.

In their paper, “Length-based Encoding of Binary Data in DNA,” which was published by the American Chemical Society last month, the researchers discovered a system to encode digital information within DNA. This method relies on the length of the fragments obtained by the partial restriction digest rather than the actual content of the nucleotide sequence. As a result, the technology eliminates the need to use expensive sequencing machinery.

Why is this discovery important? The human genome consists of the equivalent of approximately 750 megabytes of data – a significant amount of storage space. However, only about three percent of DNA goes into composing the more than 22,000 genes that make us what we are. The remaining 97 percent leaves plenty of room to encode information in a genome, allowing the information to be preserved and replicated in perpetuity.

Given the size of the DNA fragments (one base pair of DNA is 0.33 nanometers), one could store a large amount of information in a very small space. By storing messages within DNA, organizations can “tag” objects to verify authenticity, as well as to inconspicuously send data to a specific destination.

“Already there are several companies using DNA to tag objects that they certify to be original and which then can be very difficult to counterfeit,” says Stefano Lonardi, Associate Professor of Computer Science & Engineering at UCR’s Bourns College of Engineering.

For example, the British company, Redweb Security, has developed something called i-powder that tags DNA and another company called PSA DNA Authentication services tags sports memorabilia.

“What we developed at UCR is a method to encode a message in DNA in a way that does not require an expensive sequencing machine,” notes Lonardi. “The decoding still requires a wet lab procedure, but the experimental procedure is significantly easier.”

Source: University of California, Riverside

Related stories:

Gold, DNA Combination May Lead To Nano-Sensor
The ability to use genetic material to assemble nanoscopic particles of gold could be an important step toward creating tiny “spies” that will be able to infiltrate individual cells and report back in real time on the cell’s inner workings.
Woolly-Mammoth Gene Study Changes Extinction Theory
A large genetic study of the extinct woolly mammoth has revealed that the species was not one large homogenous group, as scientists previously had assumed, and that it did not have much genetic diversity.
Scientists reveal the lifestyle evolution of wild marine bacteria
Marine bacteria in the wild organize into professions or lifestyle groups that partition many resources rather than competing for them, so that microbes with one lifestyle, such as free-floating cells, flourish in proximity with closely related microbes that may spend life attached to zooplankton or algae.
Partnerships of Deep-Sea Methane Scavengers Revealed
The sea floor off the coast of Eureka, California, is home to a diverse assemblage of microbes that scavenge methane from cold deep-sea vents. Researchers at the California Institute of Technology have developed a technique to directly capture these cells, lending insight into the diverse symbiotic partnerships that evolved among different species in an extreme environment.
The not-so-digital future of digital signal processing
Fungi processing audio signals. E. Coli storing images. DNA acting as logic circuits. It’s possible, and in some cases, it’s already happened. In any event, performing digital signal processing using organic and chemical materials without electrical currents could be the wave of the future — or so argue Sotirios Tsaftaris, research professor of electrical engineering and computer science, and Aggelos Katsaggelos, Ameritech Professor of Electrical Engineering and Computer Science, in their recently published “point of view” piece in the Proceedings of the IEEE (Institute of Electrical and Electronics Engineers.)
Researchers eliminate drug discovery bottleneck
Determining the structure of unknown natural compounds is a slow and expensive part of drug screening and development – but this may now change thanks to a new combination of experimental and computational protocols developed at the University of California, San Diego and presented at RECOMB 2008 (Research in Computational Molecular Biology) on March 31 in Singapore.
Probing Question: Is cloned meat safe to eat?
Picture the perfect steak. The first bite melts in your mouth, tender and dripping with flavor. You can barely keep chewing as your mind goes slack with joy. Yes, you could spend the rest of your life eating this same steak, over and over, with no complaint whatsoever.
On the trail of rogue genetically modified pathogens
Bacteria can be used to engineer genetic modifications, thereby providing scientists with a tool to combat many challenges in areas from food production to drug discovery. However, this sophisticated technology can also be used maliciously, raising the threat of engineered pathogens. New research published in the online open access journal Genome Biology shows that computational tools could become a vital resource for detecting rogue genetically engineered bacteria in environmental samples.

News discussion:

Nanotechnology news