[Home]   [Full version]  

Gene tied to hair pulling disorder

Sep 28 ,Medicine & Health


A Durham, N.C., study has suggested mutations in a certain gene might be related to a disorder that causes people to pull out their own hair.

Researchers at the Duke Center for Human Genetics said mutations in the SLITKR1 gene may play a role in trichotillomania, a mental disorder that causes sufferers to compulsively pull their hair out, WebMD reported Thursday.

"Society still holds negative perceptions about psychiatric conditions such as trichotillomania. But, if we can show they have a genetic origin, we can improve diagnosis, develop new therapies, and reduce the stereotypes associated with mental illness," said researcher Stephan Zuchner.

The researchers focused on the SLITRK1 gene, which has been linked to Tourette syndrome, a related impulse-control disorder, while examining the cases of 44 families containing one or more trichotillomania sufferers.

The team said it is likely that other genes also contribute to the disorder.

"The SLITRK1 gene could be among many other genes that are likely (to) interact with each other and environmental factors to trigger trichotillomania and other psychiatric conditions," said researcher Allison Ashley-Koch.

Copyright 2006 by United Press International

Related stories:

Gene triggers obsessive compulsive disorder-like syndrome in mice
Using genetic engineering, researchers have created an obsessive-compulsive disorder (OCD) - like set of behaviors in mice and reversed them with antidepressants and genetic targeting of a key brain circuit. The study, by National Institutes of Health (NIH) -funded researchers, suggests new strategies for treating the disorder.
Study provides insight on a common heart rhythm disorder
University of Iowa researchers and colleagues in France have identified a gene variant that causes a potentially fatal human heart rhythm disorder called sinus node disease. Also known as "sick sinus syndrome," the disease affects approximately one in 600 heart patients older than 65 and is responsible for 50 percent or more of the permanent pacemaker placements in the United States.
Form of Crohn's disease traced to disabled gut cells
Scientists report online this week in Nature that they have linked the health of specialized gut immune cells to a gene associated with Crohn's disease, an often debilitating and increasingly prevalent inflammatory bowel disorder.
First glimpse of a key DNA repair protein at work
Repairing breaks in the two strands of the DNA double helix is critical for avoiding cancer. In humans and other organisms, a molecular machine called the MRN complex is responsible for finding and signaling double-strand breaks (DSBs), then launching the error-free method of DNA repair called homologous recombination.
MS patients have higher spinal fluid levels of suspicious immune molecule
A protein that helps keep immune cells quiet is more abundant in the spinal fluid of patients with multiple sclerosis (MS), further boosting suspicion that the protein, TREM-2, may be an important contributor to the disease.
'Hub' of fear memory formation identified in brain cells
A protein required for the earliest steps in embryonic development also plays a key role in solidifying fear memories in the brains of adult animals, scientists have revealed. An apparent "hub" for changes in the connections between brain cells, beta-catenin could be a potential target for drugs to enhance or interfere with memory formation.
Gene variant boosts risk of fatty liver disease, scientists discover
Researchers at UT Southwestern Medical Center have found that individuals who carry a specific form of the gene PNPLA3 have more fat in their livers and a greater risk of developing liver inflammation. They also found that Hispanics are more likely to carry the gene variant responsible for higher liver-fat content than African-Americans and Caucasians.
Mapping the neuron-behavior link in Rett Syndrome
A link between certain behaviors and the lack of the protein associated with Rett Syndrome – a devastating autism spectrum disorder – demonstrates the importance of MeCP2 (the protein) and reveals never-before recognized functions associated with aggression and obesity, said researchers at Baylor College of Medicine in a report in the current issue of the journal Neuron.

News discussion:

Medicine & Health news

[Home]   [Full version]