Breast cancer more aggressive among obese women

“The more obese a patient is, the more aggressive the disease,” said Massimo Cristofanilli, MD, associate professor of medicine in the Department of Breast Medical Oncology at The University of Texas M.D. Anderson Cancer Center. “We are learning that the fat tissue may increase inflammation that leads to more aggressive disease.”

Cristofanilli and colleagues observed 606 women with locally advanced breast cancer. These women were classified by body mass index into the following three groups: normal/underweight (24.9 or below), overweight (at least 25 but less than 30) or obese (more than 30). Body mass index is calculated by dividing a person’s weight by their height.

At five years, overall survival was 56.8 percent among obese women, 56.3 percent among overweight women and 67.4 percent among normal weight women. The 10-year survival rate was 42.7 percent among obese women, 41.8 percent among overweight women and 56.5 percent among normal weight women.

The rate of inflammatory breast cancer, previously shown to have worse outcomes than non-inflammatory breast cancer, among obese women was 45 percent compared with 30 percent in overweight women and only 15 percent in women considered normal weight, researchers found.

Risk of breast cancer recurrence was also higher in obese or overweight women. By five years, 50.8 percent of obese women reported a recurrence compared with 38.5 percent of normal weight women. By 10 years, the rate of recurrence was 58 percent among obese women and 45.4 percent among normal weight women.

“Obesity goes far beyond just how a person looks or any physical strain from carrying around extra weight. Particular attention should be paid to our overweight patients,” Cristofanilli said.

Cristofanilli said physicians need to pay close attention to breast cancer patients because commonly used drugs, such as tamoxifen, tend to increase weight gain during treatment.

“We have actually become quite good at managing acute side effects such as nausea in our chemotherapy patients and it goes away within a couple of days,” Cristofanilli said.

“Following the nausea, our patients tend to overeat, which further increases their risk of weight gain. We need to implement lifestyle modifications interventions and develop better methods to follow these patients closely.”

Source: American Association for Cancer Research

Previously unseen switch regulates breast cancer response to estrogen
A tiny modification called methylation on estrogen receptors prolongs the life of these growth-driving molecules in breast cancer cells, according to research by scientists at Emory University's Winship Cancer Institute. The results are published in the May 9, 2008 issue of the journal Molecular Cell.
Much of the increased risk of death from smoking reduced within several years after quitting
Women who quit smoking significantly reduce their risk of death from coronary heart disease within 5 years and have about a 20 percent lower risk of death from smoking-related cancers within that time period, according to a study in the May 7 issue of JAMA.
Anxiety, mood disorders put cancer patients at risk for PTSD
Breast cancer patients who have a prior history of mood and anxiety disorders are at a much higher risk of experiencing posttraumatic stress disorder following their diagnosis, new research suggests.
Discovery of a novel mechanism for the development of colon cancer
Recent work from the Finnish Academy Center of Excellence on Cancer Biology at the University of Helsinki, Finland, has shed light on the mechanisms of colon tumor development and may help to design better treatment for this disease.
Second breast cancer may be greater than thought for high-risk women without BRCA mutations
A preliminary analysis of ongoing research suggests that high-risk women with breast cancer who do not have a BRCA1/2 mutation may face a greater chance for developing a second breast cancer than previously thought. With the increased risk of cancer in these women, should sentinel node biopsy be considered at the time of prophylactic mastectomy, and how can women best be counseled after these findings?
Some women more likely to miss or ignore heart attack warning signs
Many women under age 55 aren’t seeking timely treatment for heart attack because they expect the warning signs and their reaction to follow a Hollywood script — tightening in the chest, shortness of breath, clutching the chest while dropping to one knee.
Better-educated women are a healthier weight, new research reveals
A new comparison of multi-national data, released this month, reveals that highly educated women have a healthier average weight than less educated women, but that the meaning of “healthier” changes according to a nation’s relative wealth. In countries where malnutrition is prevalent, better-educated women weigh more. But in wealthier countries — with rapidly growing rates of obesity — better-educated women weigh less.
Cancer fund promotes breastfeeding benefit
Three-quarters of British women are unaware that breastfeeding can protect against cancer, a survey by the World Cancer Research Fund indicated.

Breast cancer more aggressive among obese women

Related stories:

News discussion: