Breakthrough in designing complicated all-α protein structures

A team of researchers has developed an innovative method to design complicated all-α proteins, characterized by their non-uniformly arranged α-helices as seen in hemoglobin. Employing their novel approach, the team successfully ...

A new inactive form of p38α protein discovered

p38α protein, a key enzyme in the regulation of various cellular functions, plays a crucial role in some diseases, including cancer, chronic inflammation, and neurodegenerative conditions. Since the discovery of p38α, various ...

Researchers build an enzyme-discovering AI

While E. coli is one of the most studied organisms, the function of 30% of proteins that make up E. coli has not yet been clearly revealed. For this, an artificial intelligence was used to discover 464 types of enzymes from ...

Lysosomal protein driver of neurodegenerative diseases revealed

Lysosomes, tiny compartments within cells known as the garbage disposals for molecules that need to be degraded, are critical to cell function and a person's health; disruption of lysosomal protein function is linked to a ...

HPV discovery yields breakthrough in understanding protein activity

A new study led by Yale scientists shows that the activity of a portion of a human papillomavirus (HPV) protein does not depend on its amino acid sequence or composition. This discovery challenges the widely held belief that ...

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