While the first genome-wide DNA methylation map in mammalian cells was established over 10 years ago, such maps only provide snapshots and do not inform about the actual dynamics of this epigenetic mark. Researchers from ...
Biotechnology
Jun 2, 2020
0
16
A team from the Broad Institute of MIT and Harvard has developed a new CRISPR genome-editing approach by combining two of the most important proteins in molecular biology—CRISPR-Cas9 and a reverse transcriptase—into a ...
Biotechnology
Oct 21, 2019
2
339
Scientists routinely use genetic screens to perturb, or change the activity of, genes in mammalian cells, one at a time, to learn what those genes do. Pooled screens take this same approach but typically involve many more ...
Molecular & Computational biology
Oct 18, 2019
0
34
Wake Forest Institute for Regenerative Medicine scientists have fine-tuned their delivery system to deliver a DNA editing tool to alter DNA sequences and modify gene function. The improved "hit and run" system works faster ...
Biotechnology
Sep 13, 2019
3
183
A look at the brains of an endangered spiny rat off the coast of Japan by University of Missouri (MU) Bond Life Sciences Center scientist Cheryl Rosenfeld could illuminate the subtle genetic influences that stimulate a mammal's ...
Plants & Animals
Jan 31, 2019
0
3
Transcription activator-like effector (TALE) proteins can be designed to bind to almost any selected DNA. Researchers now report that a TALE can displace another TALE protein from DNA in a highly polarized way – it can ...
Cell & Microbiology
Nov 26, 2018
0
27
The definitive architecture of the mammalian body is established shortly after implantation of the embryo in the uterus. The antero-posterior, dorso-ventral and medio-lateral axes of the body become organized under the control ...
Cell & Microbiology
Oct 3, 2018
0
34
Complex reaction cascades can be triggered in artificial molecular systems: Swiss scientists have constructed an enzyme than can penetrate a mammalian cell and accelerate the release of a hormone. This then activates a gene ...
Biochemistry
May 22, 2018
0
5
Researchers from North Carolina State University have demonstrated a connection between the expression of the HMGA2 gene and body size in pigs. The work further demonstrates the gene's importance in body size regulation across ...
Biotechnology
May 7, 2018
4
141
In mammalian cells, the transcription factor p53 most responsible for healthy growth of the organism. The equivalent in plants is Suppressor Of Gamma Response 1 (SOG1), a factor that does not share a common evolutionary ancestor ...
Cell & Microbiology
Mar 2, 2018
0
10
